Kidnapped while attending a religious conference in the Middle East, American journalist Doug Rawlins is a hostage of the Iranian regime on trial for trumped-up charges of espionage. With no help from her State Department connections, Doug's wife Liz decides to take matters into her own hands to find her husband and bring him home. Inspired by true events and, Infidel casts light on the plight of the Americans currently held captive in Iran.

17-year-old Griet must work to support her family, so she becomes a maid in the house of Johannes Vermeer, where she attracts the master painter's attention. He is commissioned to paint Griet, and the result is one of the greatest paintings ever created.