Peter Parker, a.k.a. Spider-Man, is desperately trying to balance his dual identities. He can't keep up at college, pay his rent, or seem to make amends with his estranged best friend Harry and his beloved Mary Jane is more skeptical than ever. Peter begins to notice that he's losing some of his powers and wonders if the cost of being a superhero isn't too high. Meanwhile Peter's idol, the renowned scientist Otto Octavius, has turned into a maniacal...

Grace and Jonathan Fraser have the life they've always wanted: she's a successful therapist, he's an acclaimed pediatric oncologist, and their son attends an elite private school in Manhattan. But for Grace, everything unravels overnight with a violent death and a missing husband.