As a CIA officer, Evelyn Salt swore an oath to duty, honor and country. Her loyalty will be tested when a defector accuses her of being a Russian spy. Salt goes on the run, using all her skills and years of experience as a covert operative to elude capture. Her efforts to prove her innocence only serve to cast doubt on her motives, as the hunt to uncover the truth behind her identity continues.

Retired black-ops CIA agent Frank Moses rejoins his unlikely team of elite operatives for a global quest to track down a missing portable nuclear device.